The control diet, which followed dietary recommendations in each participating nation, had a moderate protein content and did not include instructions to participants with regards to the glycemic index. Study participants were instructed to keep their weight loss in this phase, although further fat loss was allowed. All five diet plans were designed to possess a moderate fat content with no restrictions on energy consumption , in order to test the ability of the diets to regulate body and appetite fat.A total of 69.2 percent of 39 individuals with high-grade dysplasia and 42.4 percent of 99 participants with sessile serrated polyps measuring 1 cm or larger were identified on DNA assessment . The sensitivity of the DNA check was higher for distal advanced precancerous lesions than for proximal lesions ; check sensitivity improved as the lesion size increased . The sensitivity for the detection of cancers or advanced precancerous lesions didn’t differ significantly according to age group or laboratory-tests site . Among 9167 individuals who had findings apart from colorectal cancers or advanced precancerous lesions , the specificity of the DNA check was 86.6 percent . Among the 4457 individuals with negative outcomes on colonoscopy totally, the specificity was 89.8 percent ; within this subgroup, the specificity was 94.0 percent among participants younger than 65 years and 87.1 percent among those 65 years of age or older .