Our data show that CXCL4 levels correlated with disease phenotype and disease progression in five large highly, independent, and clinically well-characterized patient cohorts, whereas levels of CCL2, CXCL10, CCL5, von Willebrand aspect, and CCL18 didn’t show such correlation. Taken together, our observations claim that CXCL4 and plasmacytoid dendritic cells are central to the pathogenesis of systemic sclerosis. The degrees of CXCL4 correlated well with the amount of fibrosis and the occurrence and progression of pulmonary arterial hypertension, both clinical hallmarks of the disorder.Over fifty % the patients received 69 mg of doxorubicin per square meter of body-surface region for at least one cycle and cumulative doses of 345 to 507 mg per square meter. To assess cardiac toxic effects, ejection fractions were measured in 42 individuals. All had normal ejection fractions up to a decade after treatment . There is no significant relationship between the ejection fraction and the amount of time since treatment or between your ejection fraction and the cumulative doxorubicin dosage , and no significant interaction between your dose and period interval .